Chronic Pain & Migraine Treatment in Cardiff-by-the-Sea, CA

Ketamine Therapy for Chronic Pain & Migraines in San Diego

IV ketamine infusions target NMDA receptors and central sensitization — the brain’s amplification of pain signals. Combined with stellate ganglion block, metabolic optimization, and lifestyle medicine, we treat chronic pain at its neurological roots, not just its symptoms.

Your Brain Has Learned to Amplify Pain

Central sensitization is a neurological state where your brain and spinal cord amplify pain signals, creating pain out of proportion to (or independent of) tissue damage. This is the mechanism underlying chronic pain conditions like CRPS, fibromyalgia, chronic migraines, neuropathic pain, and persistent post-surgical pain. Opioids often make central sensitization worse through opioid-induced hyperalgesia.

The Opioid Trap and the NSAID Ceiling

Opioids address pain temporarily but create dependence, tolerance, and paradoxically increased pain sensitivity over time. NSAIDs and acetaminophen have a ceiling effect and can’t address the central nervous system changes driving chronic pain. Gabapentinoids help some patients but cause cognitive dulling and weight gain. None of these approaches reverse the neurological changes at the heart of chronic pain.

The Inflammation-Pain Connection

Chronic pain is intimately linked to systemic inflammation, metabolic dysfunction, and mitochondrial impairment. Research shows elevated inflammatory markers in chronic pain patients, and dietary interventions that reduce inflammation can significantly impact pain levels. Magnesium deficiency alone — present in up to 50% of Americans — can drive muscle pain, headaches, and neuronal hyperexcitability.

response rate to ketamine in chronic pain conditions including CRPS and fibromyalgia
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typical duration of pain-protocol IV ketamine infusions (higher dose than mood protocols)
4- Hours
receptor modulation: ketamine’s primary mechanism for reversing central sensitization
NMDA
ketamine treatments administered by Dr. Gillin
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Why Standard Pain Management Falls Short

Most conventional depression treatment focuses narrowly on symptom suppression. While SSRIs can be helpful for some patients, they represent just one small piece of a much larger biological puzzle.

The Seaside Method: A Smarter Path Forward

RAPID RELIEF

IV ketamine infusions using pain-specific protocols that directly target NMDA receptors and reverse central sensitization. Stellate ganglion block for sympathetically-mediated pain conditions.

  • Pain-protocol ketamine infusions (higher dose, longer duration than mood protocols)
  • Stellate ganglion block for CRPS, complex regional pain, and sympathetically-mediated conditions
  • tVNS for neuroinflammation modulation

ROOT CAUSE

Comprehensive metabolic assessment of pain drivers through Seaside Longevity.

  • Inflammatory markers panel
  • Nutrient status (magnesium, D, B12, omega-3)
  • Hormonal assessment
  • Metabolomic profiling
  • Pharmacogenomic testing

REWIRE & REBUILD

Neuroplasticity-based retraining of pain processing circuits.

  • Pain neuroscience education
  • The Gupta Program for central sensitization
  • Mindfulness-based stress reduction for pain
  • Graded movement and exposure

RESILIENCE

Anti-inflammatory lifestyle and pain self-management.

  • Anti-inflammatory nutrition protocol
  • Movement programming
  • Sleep optimization
  • Stress management
  • Opioid taper support when appropriate

WHAT TO EXPECT

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Free Consultation

Discuss your pain history and determine if ketamine therapy is appropriate.

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Medical Evaluation

Comprehensive pain assessment, safety screening, and metabolic lab orders.

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Treatment Plan

Pain-specific ketamine protocol plus metabolic optimization and integration therapies.

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Treatment Sessions

IV infusions in our calm setting with continuous monitoring. Pain protocols are typically 4-6 hours.

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Optimization

Ongoing pain management, metabolic optimization, and building of self-regulation tools.

After years of getting nowhere with my regular doctor, I finally feel like someone is actually listening — and figuring out what’s really going on.
— Eric H., Seaside Ketamine Patient

FAQ

Q: How does ketamine treat chronic pain?

A: Ketamine is an NMDA receptor antagonist. By blocking NMDA receptors, it can reverse central sensitization — the brain’s amplification of pain signals that underlies many chronic pain conditions. This mechanism is distinct from how opioids work, and ketamine does not carry the same addiction risk.

A: Conditions with strong evidence for ketamine treatment include CRPS (complex regional pain syndrome), fibromyalgia, chronic migraines, neuropathic pain, central sensitization syndromes, and persistent post-surgical pain. A comprehensive evaluation helps determine if ketamine is appropriate for your specific condition.

A: Yes. Pain-protocol infusions typically use higher doses and longer durations (4-6 hours) compared to mood protocols (typically 40-60 minutes). The higher dose and extended duration are needed to adequately block NMDA receptors and reverse central sensitization.

A: Many patients are able to reduce or eliminate opioid use after ketamine treatment, as it addresses the central sensitization that was driving their pain. We provide medically supervised opioid taper support when appropriate.

A: Yes. Ketamine has shown efficacy for chronic migraines, particularly those that haven’t responded to standard treatments. It works through NMDA receptor modulation and may also reduce the neuroinflammation and cortical spreading depression involved in migraine pathophysiology.

A: A stellate ganglion block is an ultrasound-guided injection near a key sympathetic nerve cluster. For pain conditions with a sympathetic component (like CRPS), SGB can provide significant relief by blocking abnormal sympathetic nerve activity. It has been used for decades in pain management.

A: Chronic inflammation lowers pain thresholds, amplifies pain signaling, and maintains central sensitization. Inflammatory cytokines directly sensitize pain-sensing neurons. Through metabolic assessment via Seaside Longevity, we identify and address inflammatory drivers including diet, gut health, and metabolic dysfunction.

A: Pain protocols typically involve a series of infusions. Many patients start with 4-6 infusions over 1-2 weeks and then transition to maintenance infusions as needed. Response varies by condition and individual.

Pain Has Stolen Enough of Your Life. There’s Another Way.

If opioids and standard treatments haven’t given you real relief, ketamine therapy may reverse the neurological changes driving your pain.

Free 15-minute call. Physician-led care. Evidence-based protocols.