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Ketamine Therapy for Depression in San Diego

Standard antidepressants often fail to resolve severe depression. Therefore, we provide physician-led ketamine therapy to create rapid brain healing. Furthermore, we use metabolic psychiatry to treat underlying root causes like inflammation and hormone imbalances. Ultimately, this complete approach provides fast and lasting relief

seaside ketamine san diego

You’re Not Lazy. Your Brain Is Running on Empty.

Depression isn’t a character flaw. Emerging research from Harvard’s Dr. Christopher Palmer and Stanford’s Dr. Shebani Sethi reveals that depression is often a metabolic disorder — your brain’s mitochondria aren’t producing enough energy, inflammation is disrupting neural circuits, and your neuroplasticity has ground to a halt. No amount of push can reset broken biology.

The Medication Merry-Go-Round

You’ve tried SSRIs, SNRIs, maybe even augmentation strategies. The STAR*D trial found that after four rounds of medication trials, only about one third of patients achieve remission. Meanwhile, side effects grow: weight gain, sexual dysfunction, emotional blunting. There’s a reason you feel stuck — the standard approach is treating symptoms while missing the biological machinery driving them.

What Nobody Told You About Your Depression

Your depression may be driven by insulin resistance (affecting up to 40% of depressed patients), chronic inflammation (elevated hs-CRP and IL-6), thyroid dysfunction, gut dysbiosis, vitamin D or B12 deficiency, magnesium depletion, or mitochondrial dysfunction. These aren’t fringe theories — they’re published in the world’s leading psychiatric journals. Yet most providers never test for them.

of patients with treatment-resistant depression respond to ketamine therapy (multiple meta-analyses)
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Time to first noticeable antidepressant effects with IV ketamine (vs. 4-6 weeks for SSRIs)
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of treatment-refractory psychiatric inpatients achieved clinical remission on ketogenic metabolic therapy (Danan et al., 2022)
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ketamine treatments administered by Dr. Gillin in a medically supervised setting
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Why Antidepressants Alone Aren’t Enough

Most conventional depression treatment focuses on symptom calming. While SSRIs can be helpful for some patients, they represent just one small piece of a much larger biological puzzle.

Side Effects of Ketamine Therapy | San Diego Guide

The Seaside Method: A Smarter Path Forward

RAPID RELIEF

Ketamine Therapy (IV, IM, or Spravato) creates rapid neuroplasticity, breaking the rigid neural patterns of depression within hours to days rather than weeks to months.

  • IV ketamine infusions: medical-grade, monitored, personalized dosing
  • IM ketamine: flexible option for patients who prefer intramuscular delivery
  • Spravato (esketamine): FDA-approved, often covered by insurance for treatment-resistant depression

ROOT CAUSE

Metabolic Psychiatry Assessment through Seaside Longevity: comprehensive lab work evaluating inflammation, hormones, gut health, mitochondrial function, nutrient status, insulin resistance, pharmacogenomics, and metabolomic profiling.

  • Complete metabolic panel + fasting insulin + HbA1c
  • Inflammatory markers: hs-CRP, IL-6, TNF-alpha, homocysteine
  • Complete thyroid: TSH, Free T3, Free T4, reverse T3, thyroid antibodies
  • Hormonal panel: cortisol (4-point), DHEA-S, testosterone, estradiol, progesterone
  • Gut health: GI-MAP comprehensive stool analysis
  • Nutrient status: vitamin D, B12, folate, RBC magnesium, zinc, copper, omega-3 index
  • Organic acids testing for mitochondrial function markers
  • Pharmacogenomic (PGx) testing for medication optimization
  • Metabolomic profiling for personalized supplement protocols

REWIRE & REBUILD

Integration therapies to leverage the neuroplastic window created by ketamine and address psychological root causes.

  • Ketamine-Assisted Psychotherapy (KAP) with trained therapists
  • Compassionate Inquiry (Gabor Maté methodology) for trauma and attachment work
  • The Gupta Program for neuroplasticity-based retraining of anxiety and depression circuits
  • Adapted 12-Step Framework: personal inventory, character growth, amends, daily practice
  • Mindfulness meditation and purpose-driven intention setting

RESILIENCE

Lifestyle medicine and ongoing support to build a life that sustains recovery.

  • Personalized nutrition plan (including ketogenic metabolic therapy when indicated)
  • Exercise programming optimized for mood and neuroplasticity
  • Sleep optimization protocols
  • Stress management and nervous system regulation techniques
  • Community support and ongoing check-ins
  • Medication taper support when clinically appropriate

WHAT TO EXPECT

ketamine for anxiety San Diego

Free 15 Minute Consultation

Speak directly with our team to determine if ketamine therapy is appropriate for your depression. No pressure, just clarity.

ketamine for anxiety San Diego

Comprehensive Medical Evaluation

In-depth history, symptom assessment, safety screening, and treatment planning with Dr. Gillin. Metabolic lab orders placed through Seaside Longevity.

ketamine for anxiety San Diego

Personalized Treatment Plan

Your plan may include IV ketamine, IM ketamine, or Spravato plus metabolic optimization, psychotherapy integration, and lifestyle medicine — tailored to your specific biology and goals.

ketamine for anxiety San Diego

Treatment & Integration

Each session is done in our calm, oceanfront setting with continuous medical monitoring. Integration support between sessions helps you process and apply what emerges.

ketamine for anxiety San Diego

Progress Tracking & Optimization

Regular symptom tracking, lab monitoring, medication adjustments, relapse prevention planning, and transition to maintenance protocols.

After years of getting nowhere with my regular doctor, I finally feel like someone is actually listening — and figuring out what’s really going on. I have more energy, I’m sleeping better, and I’ve even lost 15 pounds without trying. This has been life changing.
— Eric H., Seaside Ketamine Patient

FAQ

Ketamine quickly activates your brain to form new neural connections. Consequently, it creates a powerful window of healing. Therefore, your brain breaks free from rigid depressive patterns. Ultimately, you notice positive changes within hours or days instead of weeks.

Yes, research shows strong success rates for severe depression. Furthermore, doctors have studied ketamine extensively in struggling patients. Therefore, we combine this therapy with metabolic psychiatry. Ultimately, this comprehensive approach improves your overall healing outcomes.

Metabolic psychiatry reveals that underlying physical issues often drive depression. For instance, problems like inflammation and insulin resistance harm your brain. Therefore, our team tests for these hidden root causes. Furthermore, we treat these physical issues directly alongside your ketamine therapy.

Many patients notice better mood and energy within hours. However, lasting transformation requires deeper physical and mental healing. Therefore, our method combines fast relief with lasting lifestyle changes. Ultimately, this approach builds a strong foundation for your recovery.

Insurance providers frequently cover Spravato for treatment resistant depression. However, patients usually pay out of pocket for IV ketamine. Additionally, your insurance might cover our comprehensive metabolic lab tests. Ultimately, our team will happily verify your exact coverage options.

Yes, you can continue taking your current medications safely. Furthermore, we often start ketamine therapy alongside your existing prescriptions. Eventually, our doctors can help you taper off these drugs. Consequently, we monitor all medication changes very carefully.

Most clinics only provide basic infusions without testing underlying biology. However, we combine treatments with comprehensive metabolic psychiatry and lifestyle medicine. Furthermore, we use expert testing to guide your recovery. Ultimately, we treat the actual root causes of your depression.

Patients might experience temporary light headedness, nausea, or mild changes. However, these minor effects usually vanish within two hours. Furthermore, our medical team watches every single treatment session closely. Ultimately, ketamine maintains an excellent safety record in clinic.

We design highly custom treatment plans for every patient. Typically, you will start with six initial infusions over three weeks. Afterward, you might receive occasional maintenance sessions as needed. Ultimately, your specific schedule depends on your personal healing progress.

Yes, substantial evidence strongly links metabolic health and depression. For example, recent studies show ketogenic diets improve severe psychiatric symptoms. Therefore, we always assess your metabolic factors carefully. Furthermore, our doctors may recommend specific dietary changes for your treatment.

You Don’t Have to Keep Suffering in Silence.

If you’ve tried medications and therapy without lasting relief, there’s a better path forward. The first step is a free 15-minute call with our team.

No pressure. No obligation. Just a conversation about what’s possible.